This particular error is seen with vCenter 6.5 however other version may be affected.
You may see following lines in vSphere-Client.virgo.log
[WARN ] http-bio-9090-exec-10 org.springframework.flex.core.DefaultExceptionLogger The following exception occurred during request processing by the BlazeDS MessageBroker and will be serialized back to the client: flex.messaging.MessageException: The supplied destination id is not registered with any service. at flex.messaging.MessageBroker.routeMessageToService(MessageBroker.java:1477) at flex.messaging.endpoints.AbstractEndpoint.serviceMessage(AbstractEndpoint.java:1046) at flex.messaging.endpoints.AbstractEndpoint$$FastClassByCGLIB$$1a3ef066.invoke(<generated>) at net.sf.cglib.proxy.MethodProxy.invoke(MethodProxy.java:149) at org.springframework.aop.framework.Cglib2AopProxy$CglibMethodInvocation.invokeJoinpoint(Cglib2AopProxy.java:689) at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:150) at org.springframework.flex.core.MessageInterceptionAdvice.invoke(MessageInterceptionAdvice.java:66) at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:172) at org.springframework.aop.framework.adapter.ThrowsAdviceInterceptor.invoke(ThrowsAdviceInterceptor.java:124) at org.springframework.aop.framework.ReflectiveMethodInvocation.proceed(ReflectiveMethodInvocation.java:172) at org.springframework.aop.framework.Cglib2AopProxy$FixedChainStaticTargetInterceptor.intercept(Cglib2AopProxy.java:573) at flex.messaging.endpoints.AMFEndpoint$$EnhancerByCGLIB$$4442b278.serviceMessage(<generated>) at flex.messaging.endpoints.amf.MessageBrokerFilter.invoke(MessageBrokerFilter.java:101)
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To resolve this issue, take SSH access to vCenter server. Stop and start vmware-updatemgr & vsphere-client services.
service-control --stop vmware-updatemgr service-control --stop vsphere-client service-control --start vmware-updatemgr service-control --start vsphere-client
Refer KB for more details on vCenter service stop/start.